Description
Recombinant full-length human CAMK2alpha was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_171825.
CAMK2alpha is a ser/thr protein kinase that is a member of the Ca2+/calmodulin-dependent protein kinase family. CAMK2alpha is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its Ca2+/calmodulin-dependent activity, CAMK2alpha can undergo autophosphorylation, resulting in Ca2+/calmodulin-independent activity. The protein level of CAMK2alpha fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2alpha increased with heightened neuronal activity (2)